Publication date: Jul 02, 2025
Community-acquired pneumonia (CAP) represents a significant health burden. We aimed to map the plasma proteome in patients with CAP and associate protein abundance with pathophysiology, tissue source, and outcome. We measured the plasma proteome of CAP patients upon admission to a general ward using Olink technology (derivation cohort). Additional Olink measurements were performed in CAP patients admitted to the intensive care unit (ICU) and SARS-CoV-2 pneumonia patients across care settings (validation cohorts). Of 2676 proteins analysed in 93 ward-CAP patients and 21 healthy controls, 904 (33. 8%) were higher in CAP, 396 (14. 8%) lower, and 1376 (51. 4%) not different. More abundant proteins were associated with innate immune and mitosis pathways, and mainly originated from lung and cardiac tissue. 131 proteins associated with time to clinical stability (TCS), of which 124 (primarily related to monocyte/macrophage and RNA processing) were connected with a long TCS. Most TCS-associated proteins were differentially abundant in non-survivors versus survivors amongst 88 ICU-CAP (1. 4- to 3. 5-fold higher) and 305 SARS-CoV-2 pneumonia patients (1. 16- to 1. 35-fold lower or 1. 14- to 2. 65-fold higher; all p
| Concepts | Keywords |
|---|---|
| Cardiac | biomarkers |
| Pathophysiology | clinical stability |
| Pneumonia | long-term development |
| Proteins | pneumonia |
| proteomics |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Pneumonia |
| disease | IDO | protein |