Publication date: Jun 30, 2025
We aimed to understand factors that distinguish vaccine hesitancy from early uptake or refusal to inform public health strategies for the next emergent infectious disease pandemic and clinician-patient communication around vaccine decision-making. The study included 10,176 participants of the Colorado Center for Personalized Medicine biobank who completed a survey in Summer 2021 which included information on COVID-19 vaccine hesitancy, attitudes, and uptake. Survey data were linked to electronic health records prior to the COVID-19 pandemic to catalogue pre-existing health conditions. Early COVID-19 vaccine uptake was high (N=9,873, 96.1%), consistent with high health literacy in this population. While many demographic factors, vaccine considerations, and pre-existing conditions distinguished early uptake from hesitancy or refusal (P
| Concepts | Keywords |
|---|---|
| Colorado | Anschutz |
| Gignoux12 | Aurora |
| Rheumatology | Colorado |
| Vaccine | Conditions |
| Covid | |
| Early | |
| Existing | |
| Factors | |
| Hesitancy | |
| Pre | |
| Preprint | |
| Refusal | |
| Uptake | |
| Usa | |
| Vaccine |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | IDO | infectious disease pandemic |
| disease | MESH | COVID-19 pandemic |
| drug | DRUGBANK | Methylphenidate |