Changes in the epidemic patterns of respiratory pathogens of children in guangzhou, China during the COVID-19 pandemic.

Publication date: Jul 01, 2025

To investigate the epidemiological characteristics of pediatric respiratory pathogens in Guangzhou, China, from 2018 to 2023 in the context of the COVID-19 Pandemic and to evaluate the impact of non-pharmaceutical interventions (NPIs) on the transmission dynamics and seasonal patterns of respiratory pathogens. A retrospective analysis was conducted at Guangzhou Women and Children’s Medical Center between January 2018 and December 2023. Pediatric patients who underwent the respiratory pathogens tests were enrolled in the study and divided into four groups by age: Infant group, Toddler group, Preschool group, and School-age group. The nasopharyngeal swab or bronchoalveolar lavage fluid (BALF) samples were collected for real-time fluorescence quantitative polymerase chain reaction (qPCR) test of respiratory pathogens. Ten common respiratory pathogens, including respiratory syncytial virus (RSV), Mycoplasma pneumoniae (MP) and Influenza A virus (FluA), were detected. In addition, the study period was divided into three phases: Pre-COVID-19 (2018-2019), COVID-19 (2020-2022), and Post-COVID-19 (2023). Detection rates, distribution patterns, and seasonal variations of respiratory pathogens were analyzed between different phases and different age groups. This study included 317,828 pediatric patients (median age: 3. 4 years, IQR: 1. 3-6. 0), from whom 1,160,764 respiratory pathogen tests were conducted. The overall pathogen detection rate was 8. 02% (93,108/1,160,764). The positive rate during the COVID-19 phase (18. 44%, 95% CI 14. 89-22. 00%) was significantly lower than that of the Pre-COVID-19 (27. 55%, 95% CI 23. 95-31. 16%) and Post-COVID-19 (27. 15, 95% CI 21. 47-32. 84%) phases (P 

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