COVID-19 Patients Have Peripheral Microvascular Dysfunction and Tissue Hypoxia in Spite of Successful Treatment of Lung Failure: A Proof of Concept Study.

Publication date: Jul 01, 2025

Availability of oxygen (O) is essential for life and function of all cells of the human body (n ≈ 10-10 cells). COVID-19 patients often have impaired lung function with compromised oxygen uptake, but little is known about microvascular oxygen delivery and tissue oxygenation. Use the Oxygen Delivery Index (ODIN) concept to assess peripheral microvascular regulation and oxygen extraction in COVID-19 patients. The ODIN concept includes two technologies (diffuse reflectance spectroscopy-DRS and computer assisted microscopy-CAM) for data acquisition from subepidermal nutritive capillaries. Output parameters are microvascular oxygen saturation (SmvO) and functional capillary density (FCD). Forty patients hospitalized for COVID-19 grouped into early discharge (

Concepts Keywords
Drs Adult
Lung Aged
N10 COVID-19
Nutritive COVID‐19
Odin diffuse reflectance spectroscopy
Female
Humans
Hypoxia
Male
microcircualtion
Microcirculation
Microvessels
Middle Aged
ODIN concept
Oxygen
Oxygen
Oxygen Saturation
Respiratory Insufficiency
SARS-CoV-2
tissue oxygenation

Semantics

Type Source Name
disease MESH COVID-19
disease MESH Hypoxia
drug DRUGBANK Oxygen
disease MESH Long Covid
disease MESH Respiratory Insufficiency

Original Article

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