Evaluating the effectiveness of a novel cost-effective aerosol containment chamber for high-risk autopsies: a pilot study.

Publication date: Jul 02, 2025

Autopsy personnel face substantial occupational risks from exposure to infectious agents, particularly during aerosol-generating procedures like bone sawing. The COVID-19 pandemic highlighted these dangers, underscoring the need for innovative safety solutions in resource-limited settings without negative-pressure autopsy suites. To address this, we developed a Low-Cost Infection Containment Chamber (LCICC)-a full-length, transparent, and impermeable structure designed to contain aerosols during high-risk autopsy procedures. This study evaluated the efficacy of LCICC using goat skulls to simulate aerosol generation during sawing. Aerosol densities were measured under both open-air conditions and with LCICC use, employing fluorescein dye for visualization and particle counter for quantification. Statistical analysis confirmed the chamber’s effectiveness in reducing occupational exposure. LCICC demonstrated a substantial reduction in aerosol levels, ranging from 85. 96 to 88. 38% across all particle sizes. Median aerosol densities were consistently recorded at 10. 50 mg/m^3 with LCICC use, compared to 74. 80 to 90. 40 mg/m^3 in open-air conditions. LCICC’s affordability, ease of assembly, and reliable performance position it as a groundbreaking tool for protecting healthcare workers, particularly in low-resource settings. This innovation addresses critical gaps in autopsy safety protocols, offering a practical solution to mitigate risks associated with infectious aerosols while advancing occupational health standards in forensic pathology.

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