Mapping brain changes in post-COVID-19 cognitive decline via FDG PET hypometabolism and EEG slowing.

Publication date: Jul 02, 2025

Cognitive decline is a common symptom of post-COVID-19 syndrome. However, the mechanisms underlying this deficit remain poorly understood. This study aims to investigate the relationship between brain metabolic and neurophysiological alteration patterns in patients with persistent subjective cognitive decline after mild COVID-19 using joint FDG-PET and EEG analyses. The study was conducted on 28 post-COVID-19 patients with cognitive decline, who underwent comprehensive clinical evaluation including cognitive testing, FDG-PET imaging, and EEG acquisition. Voxelwise statistical analysis of PET images was performed by comparing post-COVID-19 patients with healthy controls (p-voxel 

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Concepts Keywords
Covid Aged
Mapping Brain
Neurophysiological Brain Mapping
Slowing Case-Control Studies
Cognitive Dysfunction
COVID-19
Electroencephalography
Female
Fluorodeoxyglucose F18
Fluorodeoxyglucose F18
Humans
Male
Middle Aged
Positron-Emission Tomography
SARS-CoV-2

Semantics

Type Source Name
disease MESH COVID-19
disease MESH cognitive decline
disease IDO symptom
disease MESH syndrome
disease MESH Long Covid
drug DRUGBANK Albendazole

Original Article

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