Post-COVID Versus Non-COVID Myocarditis: Comparison of Morphological Activity, Toll-like Receptor Distribution and Responses to Immunosuppressive Therapy.

Publication date: Jun 27, 2025

A prior direct clinical and morphological comparison between non-coronavirus disease (COVID) myocarditis diagnosed before the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) pandemic and post-COVID myocarditis has not been performed. To compare morphological activity, Toll-like receptor distribution, and response to immunosuppressive therapy in patients with non-COVID and post-COVID myocarditis. In total, 77 patients (52 male and 25 female, 48. 7 +/- 11. 7 years old) with biopsy-proven myocarditis, New York Heart Association (NYHA) class 2 or higher heart failure diagnoses, and an ejection fraction (EF)

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Concepts	Keywords
Biopsy	Adult
Coronavirus	corticosteroids
Covid	COVID-19
Myocarditis	endomyocardial biopsy
Old	Female
	Humans
	Immunosuppressive Agents
	Immunosuppressive Agents
	immunosuppressive therapy
	Male
	Middle Aged
	Myocarditis
	Myocardium
	post-COVID myocarditis
	SARS-CoV-2
	Toll-Like Receptor 9
	Toll-Like Receptor 9
	Toll-Like Receptors
	Toll-Like Receptors
	toll-like receptors

Semantics

Type	Source	Name
disease	MESH	Myocarditis
pathway	KEGG	Coronavirus disease
disease	MESH	heart failure
disease	MESH	severe acute respiratory syndrome
disease	MESH	COVID-19

Original Article

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