Publication date: Jul 13, 2025
This paper proposed a delayed fractional-order SEIHR-M model incorporating media influence to investigate the transmission dynamics of COVID-19 in Malaysia. By integrating fractional-order dynamics and time-delay media influence into a unified epidemic framework, this novel structure more accurately captures both memory effects and behavioral response lags in the context of COVID-19. Theoretical analysis verified the existence, non-negativity, and boundedness of the solutions, ensuring the biological feasibility of the model. The basic reproduction number [Formula: see text] was derived using the next-generation matrix method, serving as a key metric for evaluating disease transmission and model stability. Furthermore, when [Formula: see text], the disease-free equilibrium is locally asymptotically stable regardless of the value of the delay parameter τ. When [Formula: see text], the stability of the endemic equilibrium exhibits two scenarios: if [Formula: see text], sufficient conditions for local asymptotic stability are provided; if [Formula: see text], there exists a critical delay [Formula: see text]. The endemic equilibrium remains locally asymptotically stable for [Formula: see text] but becomes unstable for [Formula: see text], undergoing a Hopf bifurcation at [Formula: see text], leading to periodic oscillations. The numerical simulation results not only validate the theoretical analysis but also show that as the fractional-order parameter increases, the system exhibits more pronounced oscillations; furthermore, longer delay times facilitate the emergence of these oscillatory behaviors, making the epidemic more prone to recurrent and periodic fluctuations. By fitting the model with early COVID-19 data from Malaysia, the feasibility and applicability of the model are further validated, and the superior fitting performance of the fractional-order delay model compared to the corresponding integer-order model is highlighted. Finally, sensitivity analysis results show that media interventions have a significant impact on epidemic spread, further demonstrating that timely and effective information dissemination plays a crucial role in reducing the peak of infections and controlling the epidemic.

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Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| pathway | REACTOME | Reproduction |
| disease | IDO | role |
| disease | MESH | infections |
| disease | MESH | infectious diseases |
| disease | IDO | infection |
| disease | MESH | Black Death |
| drug | DRUGBANK | Coenzyme M |
| disease | IDO | process |
| disease | MESH | viral load |
| disease | IDO | intervention |
| drug | DRUGBANK | Dihydrostreptomycin |
| drug | DRUGBANK | Stanolone |
| drug | DRUGBANK | Isoxaflutole |
| disease | MESH | death |
| drug | DRUGBANK | Etizolam |
| pathway | REACTOME | Infectious disease |
| disease | IDO | infectious disease |
| disease | MESH | secondary infections |
| disease | IDO | susceptible population |
| drug | DRUGBANK | Aspartame |
| drug | DRUGBANK | Methionine |
| drug | DRUGBANK | Resiniferatoxin |
| disease | MESH | panic |
| disease | IDO | history |
| disease | MESH | malaria |
| pathway | KEGG | Malaria |
| disease | MESH | monkeypox |
| drug | DRUGBANK | (S)-Des-Me-Ampa |
| disease | MESH | hepatitis |
| disease | MESH | dengue |
| disease | MESH | tumor |
| disease | MESH | Coronavirus Infections |