Publication date: Jul 15, 2025
Elderberry (Sambucus nigra) has received considerable attention for its health-promoting properties, particularly during the COVID-19 pandemic, when its products became one of the top-selling herbal supplements in the United States. While the anthocyanin profile of elderberry is well characterised, comprehensive studies of its non-anthocyanin constituents are underexplored. An in-depth phytochemical investigation of dried elderberry fruits, focusing on non-anthocyanin constituents, led to the discovery of a novel iridoid glycoside named elderberoside (1). Additionally, ten known metabolites were isolated, including an iridoid (2), an alkaloid (3), and eight flavonoids (4-11). Structural elucidation of these compounds was achieved through detailed one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy and confirmed by mass spectrometry.
| Concepts | Keywords |
|---|---|
| Flavonoids | elderberoside |
| Herbal | Elderberry |
| Nuclear | flavonoids |
| Pandemic | iridoid |
| Selling | Sambucus nigra |
| viburnaceae |
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Pentaerythritol tetranitrate |
| disease | MESH | COVID-19 pandemic |
| drug | DRUGBANK | Sambucus nigra flowering top |