Spatial Distribution and Post-COVID-19 Health Complications in Older People: A Brazilian Cohort Study.

Publication date: Jul 06, 2025

Background/Objectives: In the aftermath of the COVID-19 pandemic, individuals infected with SARS-CoV-2 have progressively displayed a range of symptoms linked to protracted COVID during the post-acute phase of illness. Concurrently, in several nations globally, the phenomenon of population aging has been intensifying. In this scenario, the aged population has become both vulnerable and high-risk during the acute phase of COVID-19, and faces significant dangers associated with long-COVID. This study seeks to analyze the incidence and spatial distribution of health complications in older people affected by COVID-19, in the first year of the pandemic (2020), in the State of ParancE1, as well as to identify the factors associated with the development of cardiovascular, neurological, respiratory, and metabolic diseases. Method: An observational and retrospective study was carried out in the Brazilian state of ParancE1. Participants were randomly selected from two databases. A total of 893 older people (≥60 years) participated in the study 12 months after acute COVID-19 infection. Telephone questionnaires were applied between March and December 2021. The Moran index test, logistic regression, and Poisson models were used to analyze the data. Results: In terms of age, most participants (66%) were between 60 and 69 years old, 25. 8% were between 70 and 79 years old, and 8. 2% were 80 years old or older. Most participants were female (51. 2%), white (98. 1%), had a partner (69. 8%), and had been hospitalized due to COVID-19 (59. 3%). Cardiovascular diseases were the most frequent in the population (39. 5%), followed by metabolic diseases (27. 3%). The long-term use of medication was associated with the development of metabolic diseases (aOR = 9. 8), cardiovascular diseases (aOR = 6. 6), and diseases in multiple organic systems (aOR = 3. 2); living alone was associated with neurological diseases (aOR = 2. 5), and the age group of 80 years or older (aOR = 2. 4) was associated with cardiovascular events. The spatial distribution showed that complications in body groups are distributed randomly among the health regions of the state, with no influence from neighboring locations. Conclusions: Post-COVID-19 health complications are more frequent in older adults who have comorbidities and long-term medication use. Therefore, long-term monitoring of these individuals and investment in public policies for rehabilitation and prevention of complications are necessary.

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Concepts Keywords
Databases Brazil
Models chronic disease
Old COVID-19
Pandemic older people
post-acute COVID-19 syndrome

Semantics

Type Source Name
disease MESH COVID-19
disease MESH Complications
disease MESH metabolic diseases
disease MESH infection
disease MESH Cardiovascular diseases
disease MESH living alone
disease MESH Long Covid
drug DRUGBANK Ranitidine
disease MESH chronic disease
disease MESH autoimmunity
disease MESH Hypertension
disease MESH Diabetes Mellitus
disease MESH Dyslipidemia
disease MESH sedentary lifestyle
disease MESH morbidities
disease IDO susceptibility
disease MESH lifestyle
disease IDO country
disease MESH Influenza
disease IDO process
disease MESH thrombosis
disease MESH cardiac arrhythmia
disease MESH atherosclerosis
disease MESH stroke
disease MESH obesity
disease MESH Alzheimer’s disease
disease MESH epilepsy
disease MESH respiratory diseases
disease MESH pneumonia
disease MESH asthma
pathway KEGG Asthma
disease MESH bronchiectasis
disease MESH bronchitis
disease MESH COPD
disease MESH pneumoconiosis
disease MESH marital status
disease IDO history
disease IDO symptom
disease MESH embolism

Original Article

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