Correlation between fatigue and pulmonary involvement in the post-COVID-19 condition: a cross-sectional study 6-12 months after hospital discharge.

Publication date: Jul 13, 2025

Post-COVID-19 conditions (PCC) may include pulmonary sequelae, fatigue and other symptoms, but its mechanisms are not fully elucidated. This study investigated the correlation between fatigue and the presence of pulmonary abnormalities in PCC patients with respiratory involvement 6-12 months after hospitalisation. Cross-sectional study. A tertiary hospital in Brazil. 315 patients, aged ≥18 years, were considered eligible based on SARS-CoV-2 infection confirmed by reverse transcription-PCR. Pulmonary function tests (PFT), cardiopulmonary exercise tests (CPET), chest CT and hand grip were performed. The following scales were applied: Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale, Euroqol 5 Dimensions quality of life (EQ-5D) and Hospital Anxiety and Depression Scale (HADS). Participants were divided between the fatigue group (FACIT-F≤30) and the non-fatigue group (FACIT-F>30). For the statistical analysis, the primary outcome was the difference in the diffusing capacity of the lungs for carbon monoxide (DLCO) between groups. Considered secondary outcomes were differences in PFT, CPET, chest CT, hand grip, EQ-5D and HADS. The fatigue group had 81 patients (25. 7%) against 234 (74. 3%). PFT and CPET showed no significant difference in DLCO and oxygen consumption peak values between groups. The fatigue group had a lower workload (mean 55. 3+/-21. 3 watts vs 66. 5+/-23. 2 watts, p=0. 003), higher breathing reserve (median 41. 9% (33. 8-52. 5) vs 37. 7% (28. 9-47. 1), p=0. 028) and lower prevalence of ground glass opacity (60. 8% vs 77. 7%, p=0. 003) and reticulation (36. 7% vs 54. 9%, p=0. 005) in chest CT. The fatigue group had higher anxiety (57% vs 24%, p

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