Publication date: Jul 14, 2025
The study aimed to compare corneal topographic and specular microscopic parameters before and after vaccination with activated (Pfizer -BioNTech (BNT162b2)) SARS-CoV-2 mRNA vaccine. 128 eyes of 64 patients were evaluated in this prospective study. The time interval between pre and post-vaccination examinations was nearly two and a half months (75. 6 +/- 4. 5 days). The topographic evaluation was made with Sirius corneal topography (Sirius, CSO Inc, Florence, Italy) and specular microscopy was made with Tomey EM-4000 specular microscopy (Tomey GmbH, Japan). All patients underwent detailed ophthalmologic examination including best-corrected visual acuity assessment (BCVA), measurement of intraocular pressure (IOP), anterior segment evaluation with biomicroscopy, and dilated fundus examination. The significant change in the topographic evaluation was the post-vaccine (542. 0 (534. 25-548. 0)) increase in central corneal thickness compared to pre-vaccine values (528. 0 (520. 25-537. 75) (p = 0. 001). The endothelial cell density (ECD) was 2597 (2550. 0-2646. 50) before vaccination and 2378. 0 (2299. 0-2419. 0) at least two months after vaccination (p
| Concepts | Keywords |
|---|---|
| 5days | Cornea endothelial |
| Biomicroscopy | Covid-19 |
| Bnt162b2 | specular microscopy |
| Italy | topography |
| Vaccination | vaccine |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | IDO | cell |
| disease | MESH | Covid-19 |