Publication date: Jul 16, 2025
Decision-making for management of immunosuppressive drugs in solid organ transplant patients admitted to the ICU remains controversial. This study aimed to evaluate the impact of a temporary suspension strategy (interruption of immunosuppressive drugs > 24h) on day-90 mortality and ICU-acquired infections. This multicenter observational retrospective study conducted in solid organ transplant patients admitted to nine ICUs used a Bayesian approach with priors based on a belief elicitation process conducted among a panel of experts. Among 591 enrolled patients, suspension strategy was used in 34% of them, during a median period of 5 days [IQR: 3-10]. This approach was more common in patients admitted for sepsis (38%) or COVID-19 (49%) than for non-septic causes (24%) (p
| Concepts | Keywords |
|---|---|
| Immunosuppressive | Critical care |
| Mortality | Immunosuppressive agents |
| Organ | Nosocomial infections |
| Retrospective | Organ transplantation |
| Treatment outcome |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Nosocomial infections |
| disease | MESH | causes |
| disease | MESH | COVID-19 |
| disease | MESH | sepsis |
| disease | IDO | process |
| disease | MESH | critically Ill |
| disease | MESH | infections |