Publication date: Aug 01, 2025
Impacts of asymptomatic perioperative coronavirus disease 2019 (COVID-19) on total knee (TKA) and hip arthroplasty (THA) outcomes remains unknown. We retrospectively reviewed asymptomatically screened COVID-19 cases undergoing primary TKA or THA between 2020 and 2022. Ninety-day complications, inpatient resources, repeat hospitalizations, and functional outcomes were measured for COVID-19 patients and age- and sex-matched controls. The sample size was determined based on a priori power analysis. Statistics consisted of 2 sample t-tests or Fisher’s exact test based on variable type with α = 0. 01 to correct for multiple comparisons. Of 1914 TKA and 1424 THA patients, 20 and 28 with asymptomatic COVID-19 were compared to 75 and 105 controls, respectively. While there was no statistically significant increase in relative risk for major (TKA P = .04|THA P = .12) or thromboembolic (TKA P = .21|THA P = .04) complications, the COVID-19 group experienced mortality, ischemic stroke, pulmonary embolism, and deep vein thrombosis. There was no significant difference in admission length (TKA P = .29|THA P = .22), physical therapy (TKA P = .36|THA P = .36), labs (TKA P = .57|THA P = .82), nonhome discharge (TKA P = 1|THA P = 1), or mobility (TKA P = .18|THA P = .21). The current study suggests that, while perioperative risk of asymptomatic COVID-19 does not meet the threshold for statistical significance, arthroplasty surgeons should be aware of potential mortality and morbidity and engage in shared decision-making regarding deferral of surgery, especially for patients with other comorbidities.
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| Concepts | Keywords |
|---|---|
| Coronavirus | Coronavirus |
| Inpatient | Joint replacement |
| Morbidity | Postoperative complications |
| Ninety | Preoperative screening |
| SARS-CoV-2 | |
| Silent infection |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| drug | DRUGBANK | Tacrine |
| disease | MESH | complications |
| disease | MESH | ischemic stroke |
| disease | MESH | pulmonary embolism |
| disease | MESH | deep vein thrombosis |
| disease | MESH | morbidity |
| drug | DRUGBANK | Nonoxynol-9 |
| disease | IDO | history |
| disease | MESH | Postoperative complications |
| disease | MESH | infection |
| disease | MESH | thromboembolism |
| disease | IDO | symptom |
| drug | DRUGBANK | Acetylsalicylic acid |
| disease | MESH | asymptomatic infection |
| drug | DRUGBANK | Apixaban |
| disease | IDO | process |
| disease | MESH | Comorbidity |