Pre-COVID-19 epidemiology of community respiratory viruses at a single US center reveals sex differences in influenza A and a higher ICU incidence of human metapneumovirus in the elderly population.

Publication date: Jul 18, 2025

Few studies have simultaneously examined the epidemiology and sex differences of diverse community respiratory viruses, including human metapneumovirus (HMPV), over more than one season. Given that molecular testing for community respiratory viruses was widely performed on patients at UMass Memorial Medical Center between January 2010 and December 2013, a retrospective study was conducted to examine epidemiologic features of positive subjects. Initial testing was done with rapid influenza and respiratory syncytial (RSV) virus antigen testing, with negative testing reflexed to a multiplex nucleic acid amplification platform detecting nine respiratory viruses. Four thousand ninety-eight (50. 6%) of 8092 patients tested positive for at least one virus. The majority (75. 3%) of individuals testing positive were inpatients. Rhinovirus/enterovirus was most frequently detected; influenza A was more common in older adults and RSV incidence was highest among patients 

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Concepts Keywords
Inpatients Adolescent
Ninety Adult
Rhinovirus Aged
Aged, 80 and over
Child
Child, Preschool
COVID-19
Epidemiology
Female
Human metapneumovirus
Humans
Incidence
Infant
Influenza A
Influenza A virus
Influenza, Human
Intensive Care Units
Male
Metapneumovirus
Middle Aged
Paramyxoviridae Infections
Pre-COVID-19
Respiratory Tract Infections
Respiratory virus
Retrospective Studies
SARS-CoV-2
Seasons
Sex difference
Sex Factors
United States
Young Adult

Semantics

Type Source Name
disease MESH COVID-19
pathway KEGG Influenza A
disease MESH influenza
disease IDO nucleic acid
pathway REACTOME Reproduction
disease MESH Infectious Diseases
drug DRUGBANK Influenza A virus
disease MESH Paramyxoviridae Infections
disease MESH Respiratory Tract Infections

Original Article

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