Greater fatigue is more strongly associated with reduced reward sensitivity in the long-term phase of coronavirus disease (COVID-19) than in the early phase.

Publication date: Oct 01, 2025

Fatigue and depressive mood is inherent to acute disease, but a substantial group of people report persisting disabling fatigue and depressive symptoms long after a COVID-19 infection. Infections have been shown to change decisions about engaging in effortful and rewarding activities, but it is currently unclear whether fatigue and depressive symptoms are similarly associated with decision making during early and persistent phases after a COVID-19 infection. Here, we investigated whether fatigue and depressive mood are associated with altered weighting of reward and effort in decision making at different timepoints after COVID-19 infection. We conducted an online cross-sectional study between March 2021 and March 2022, in which 242 participants (18-65 years) with COVID-19 12 weeks ago (n = 81), or no prior COVID-19 (n = 90; self-reported) performed an effort-based decision-making task. In this task, participants accepted or rejected offers in which they could exert physical effort (ticking boxes on screen, 5 levels) to gain rewards (money to be gained in a voucher-lottery, 5 levels). State fatigue and depressive mood were measured with the Profile of Mood States (POMS) prior to the task. We used mixed binomial regression analysis to test whether fatigue and depressive mood were related to acceptance rates for reward and effort levels and whether this differed between the groups. Compared with no COVID-19 and COVID-19 12 weeks group reported higher state fatigue (mean +/- SD: 20 +/- 7 vs. 14 +/- 7 and 12 +/- 6 POMS-score, respectively; both p

Semantics

Original Article