Publication date: Jul 24, 2025
“Our study showed that exposure to SARS-CoV-2, in particular spike protein, can lead to the formation of amyloid beta aggregates in both human retinal tissue and retinal organoids. “While the mechanisms of brain fog after COVID-19 are not fully understood, scientists have found that SARS-CoV-2 can induce amyloid beta accumulation in the central nervous system. “Mechanistically, the involvement of NRP1 in amyloid beta aggregation gives a specific molecular target for future investigation,” Hafler says.
| Concepts | Keywords |
|---|---|
| Alzheimer | Alzheimer |
| Amyloid | Amyloid |
| Medicine | Beta |
| Viral | Brain |
| Yale | Cov |
| Covid | |
| Fog | |
| Hafler | |
| Nrp1 | |
| Retinal | |
| Sars | |
| Says | |
| System | |
| Tissue |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Long Covid |
| disease | MESH | infection |
| disease | IDO | symptom |
| disease | MESH | ‘brain fog |
| disease | IDO | protein |
| disease | MESH | COVID-19 |
| disease | MESH | viral infections |
| disease | IDO | innate immune response |
| disease | MESH | Alzheimer’s disease |
| pathway | REACTOME | Immune System |
| disease | IDO | role |
| pathway | REACTOME | Antimicrobial peptides |
| disease | MESH | complications |
| disease | IDO | host |
| disease | MESH | dementia |
| disease | IDO | history |
| disease | IDO | production |
| disease | IDO | cell |
Original Article
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