ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants.

Publication date: Aug 01, 2025

We analyzed the receptor-binding activity and infectivity of 6 representative SARS-CoV-2 lineages in cell lines expressing angiotensin-converting enzyme 2 proteins from 54 different animal species. All viruses demonstrated infectivity in a broad range of species. Susceptible animal species could serve as natural reservoirs or intermediate hosts for SARS-CoV-2.

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Concepts Keywords
Ace2 ACE2
Genes ACE2 protein, human
Hosts Angiotensin-Converting Enzyme 2
Reservoirs Angiotensin-Converting Enzyme 2
Viruses Animals
Cell Line
coronavirus disease
COVID-19
COVID-19
Humans
One Health
Receptors, Virus
Receptors, Virus
respiratory infections
SARS-CoV-2
SARS-CoV-2
Species Specificity
Spike Glycoprotein, Coronavirus
Spike Glycoprotein, Coronavirus
viruses
zoonoses

Semantics

Type Source Name
disease IDO infectivity
disease IDO cell
pathway KEGG Coronavirus disease
disease MESH COVID-19
disease MESH respiratory infections
disease MESH zoonoses

Original Article

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