Publication date: Jul 24, 2025
Some prior studies have reported a higher risk of long-COVID in patients re-infected with SARS-CoV-2 [64,65,66], but none investigated risk of CFS/ME. found no difference in risk of CFS/ME onset , suggesting COVID-19 per se may not exert higher risk of CFS/ME compared to other respiratory infections. Many of these individuals might have inherently been at higher risk of developing CFS/ME. We found no association between CFS/ME risk and key blood biomarkers obtained during acute COVID-19. Patients could be misclassified as COVID if they were tested positive elsewhere and such misclassification likely underestimated any potential impact of the infection on the outcome. Vaccination for COVID-19 was associated with an increased risk of new-onset CFS/ME, but only among individuals who received the vaccine during the initial phase of the rollout. Alternatively, the observed lower incidence in non-White populations may reflect diagnostic disparities driven by systemic bias in healthcare settings . Females, patients with liver, autoimmune disorders, and anxiety disorders were more likely to develop the outcome.
| Concepts | Keywords |
|---|---|
| German | Cfs |
| Hispanic | Cov |
| Underserved | Covid |
| Vaccines | Disorders |
| Fatigue | |
| Findings | |
| Higher | |
| Hospitalized | |
| Infection | |
| New | |
| Onset | |
| Post | |
| Reported | |
| Risk | |
| Sars |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | IDO | susceptibility |
| disease | MESH | misdiagnosis |
| disease | IDO | acute infection |
| disease | IDO | blood |
| disease | MESH | Re-infection |
| disease | MESH | anxiety disorders |
| disease | MESH | infection |
| disease | MESH | respiratory infections |
| disease | IDO | history |
| disease | MESH | Long Covid |
| disease | MESH | education level |
| disease | MESH | relapse |
| pathway | REACTOME | SARS-CoV-2 Infection |
| disease | MESH | SARS-CoV-2 infection |
| disease | MESH | chronic fatigue syndrome |
| disease | MESH | COPD |
| disease | MESH | liver disease |
| disease | MESH | causality |
| disease | MESH | anxiety |
| disease | MESH | depressive disorder |
| disease | MESH | cognitive dysfunction |
| disease | IDO | role |