Publication date: Aug 01, 2025
Emergence of antigenically diverse SARS-CoV-2 variants may be correlated with temporal circulation patterns. We analyzed positive SARS-CoV-2 tests in the United States reported to a national, laboratory-based surveillance network and unique amino acid sequences of the S1 region of the spike protein reported to national genomic surveillance during October 2020-September 2024. We estimated SARS-CoV-2 dominant periodicities using a discrete Fourier transform, described S1 variation using the Simpson diversity index (SDI), and estimated Spearman cross-correlation coefficients between percentage change in SDI and percentage positivity. SARS-CoV-2 activity consistently peaked during July-September and December-February, and dominant periodicities were at weeks 52. 2 and 26. 1. Percentage positivity and percentage change in SDI were negatively correlated (ρ = -0. 30; p
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Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| disease | IDO | protein |
| pathway | KEGG | Coronavirus disease |
| disease | MESH | respiratory infections |
| disease | MESH | zoonoses |