Publication date: Dec 01, 2025
To date, few large studies of clinical outcomes in pediatric COVID-19 patients have been reported. Epidemiological study of the German nationwide inpatient study (GNIS). We used the GNIS to analyze all hospitalized children ≤18 years with confirmed COVID-19 diagnosis in Germany between Jan 1st and December 31st, 2020. Overall, 3360 children aged ≤18 years were hospitalized with COVID-19 infection in Germany in 2020 (49. 8 % females). Among these, 1640 (48. 8 %) were aged ≤6 years, 504 (15. 0 %) 7 – ≤12 years and 1216 (36. 2 %) were aged 13 – ≤18 years. Among these 3360 patients, 3. 3 % were treated with mechanical ventilation and 0. 23 % died in the hospital. The frequency of venous thromboembolism (0. 18 %), vasculopathy (0. 68 %), multisystem inflammatory syndrome caused by COVID-19 (0. 65 %), and diagnosis of myocarditis (0. 60 %) were low. Besides pneumonia and acute respiratory distress syndrome, obesity (OR 6. 1 [95 %CI 2. 1-18. 2], P = 0. 001), heart failure (OR 17. 0 [95 %CI 6. 8-42. 1], P
| Concepts | Keywords |
|---|---|
| December | Case-fatality |
| Germany | Childhood |
| Inpatient | COVID-19 |
| Obesity | Mortality |
| Pneumonia | Ventilation |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| disease | MESH | infection |
| disease | MESH | venous thromboembolism |
| disease | MESH | syndrome |
| disease | MESH | myocarditis |
| disease | MESH | pneumonia |
| disease | MESH | acute respiratory distress syndrome |
| disease | MESH | obesity |
| disease | MESH | heart failure |
| disease | MESH | Long Covid |