Publication date: Jul 24, 2025

This study aimed to investigate the relationship between BMI and total lumbar BMD in obese adults. The current cross-sectional study included 3,708 obese individuals. The data on BMI, total lumbar BMD, and other covariates were obtained from the National Health and Nutritional Examination Survey (NHANES) ( http://www. cdc. gov/nchs/nhanes/ ) between 2011 and March 2020 prior to the COVID-19 pandemic. Multivariate logistic regression models were utilized to investigate the association between BMI and total lumbar BMD. Smooth curve fittings and generalized additive models were used to analyze the potential non-linearity. A total of 3,708 participants (1,610 males and 2,098 females) were included in the study. In multivariate regression analysis, the association between BMI and total lumbar BMD was positive (β = 0. 003, 95% CI: 0. 002, 0. 004). This relationship still existed after being adjusted for gender, age, and race (β = 0. 003, 95% CI: 0. 002, 0. 004) and fully adjusted for all covariates (β = 0. 003, 95% CI: 0. 002, 0. 004). In threshold effect analysis, the relationship between BMI and total lumbar BMD followed a U-shaped curve, with the inflection point at 36. 1 kg/m. The present study revealed a positive association between BMI and lumbar BMD in obese adults, the association notably following a U-shaped curve with an inflection point at a BMI of 36. 1 kg/m^2.

Semantics

Original Article