Publication date: Jul 25, 2025
Other responses varied by metabolic status. While obesity increased risks like persistent lung damage and longer-term weight loss, lean animals were more likely to develop signs of metabolic disruption. “Some parameters changed more robustly in obese animals, while others changed more robustly in lean animals. Levels of virus in the respiratory system, viral antibodies, and inflammatory factors in the blood were generally similar between lean and obese animals. DOI: 10. 1371/journal. ppat. 1012988Because many long-term effects were physiological rather than symptomatic, the study suggests long COVID may be more common than human self-report data indicates. The majority of animals had consistently altered parameters months after the resolution of initial infection. (2025) Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates, PLOS Pathogens (2025). This suggests that long COVID can indeed result from a mild infection.
| Concepts | Keywords |
|---|---|
| Macaques | Acute |
| Obesity | Animals |
| Pathology | Cov |
| Viral | Covid |
| Infection | |
| Journal | |
| Lean | |
| Long | |
| Metabolic | |
| Obese | |
| Obesity | |
| Pathogens | |
| Sars | |
| Term | |
| Virus |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | IDO | disease course |
| disease | MESH | restlessness |
| drug | DRUGBANK | Leptin |
| disease | MESH | weight loss |
| disease | IDO | blood |
| disease | MESH | acute disease |
| disease | MESH | sequelae |
| disease | MESH | Obesity |
| disease | MESH | COVID-19 |
| disease | IDO | process |
| disease | MESH | infection |
| disease | MESH | hyperplasia |
| pathway | REACTOME | SARS-CoV-2 Infection |
| disease | MESH | metabolic disease |
| disease | MESH | long COVID |