Previously undetectable biomarkers in gut microbiome may predict ‘invisible’ chronic fatigue syndrome, long COVID

Previously undetectable biomarkers in gut microbiome may predict ‘invisible’ chronic fatigue syndrome, long COVID

Publication date: Jul 26, 2025

These include sleep disturbances, headaches, fatigue, dizziness, and other symptoms the researchers mapped in their entirety from microbiome changes to metabolites, immune responses, and clinical symptoms. “Despite diverse data collection methods, common disease signatures emerged in fatty acids, immune markers, and metabolites,” Oh said. “New research by The Jackson Laboratory, Duke University, and the Bateman Horne Center reveals that chronic fatigue syndrome (ME/CFS) may leave detectable biological fingerprints in the body. “We integrated clinical symptoms with cutting-edge omics technologies to identify new biomarkers of ME/CFS,” Oh said. “To conduct the study, the researchers analyzed comprehensive data collected from the Bateman Horne Center, a leading ME/CFS, long COVID, and fibromyalgia research center in Salt Lake City, Utah. Dr. “Our goal is to build a detailed map of how the immune system interacts with gut bacteria and the chemicals they produce,” Oh said. “Our data indicate these biological disruptions become more entrenched over time,” Unutmaz said.

Concepts Keywords
Driving Bateman
Fibromyalgia Biomarkers
Microbiologist Cfs
Utah Chronic
Covid
Fatigue
Gut
Immune
Individuals
Long
Microbiome
Said
Symptoms
Syndrome
Unutmaz

Semantics

Type Source Name
disease MESH chronic fatigue syndrome
disease MESH long COVID
disease IDO process
pathway REACTOME Immune System
pathway REACTOME Metabolism
disease IDO blood
disease MESH syndrome
disease MESH abnormalities
disease MESH chronic pain
disease MESH viral infections
disease MESH lifestyle
disease MESH fibromyalgia
disease IDO cell
disease IDO symptom
drug DRUGBANK Pentaerythritol tetranitrate
disease MESH sleep disorders
drug DRUGBANK Butyric Acid
disease MESH inflammation
disease MESH tryptophan
drug DRUGBANK L-Tryptophan
pathway REACTOME Fatty acids
disease IDO bacteria

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