Simple simulation based reconstruction of incidence rates from death data.

Publication date: Jul 03, 2025

Daily deaths from an infectious disease provide a means for retrospectively inferring daily incidence, given knowledge of the infection-to-death interval distribution. Existing methods for doing so rely either on fitting simplified non-linear epidemic models to the deaths data or on spline based deconvolution approaches. The former runs the risk of introducing unintended artefacts via the model formulation, while the latter may be viewed as technically obscure, impeding uptake by practitioners. This note proposes a simple simulation based approach to inferring fatal incidence from deaths that requires minimal assumptions, is easy to understand, and allows testing of alternative hypothesized incidence trajectories. The aim is that in any future situation similar to the COVID pandemic, the method can be easily, rapidly, transparently, and uncontroversially deployed as an input to management.

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Concepts Keywords
Biometrics Biometry
Covid Computer Simulation
Daily COVID-19
Easy COVID-19
Pandemic deconvolution
England
Humans
Incidence
infection rate
lockdown
Models, Statistical
Pandemics
SARS-CoV-2

Semantics

Type Source Name
disease MESH death
disease MESH infectious disease
pathway REACTOME Infectious disease
disease MESH infection
disease MESH tics
drug DRUGBANK Methyl isocyanate
disease MESH COVID 19
drug DRUGBANK Coenzyme M
disease IDO pathogen
pathway REACTOME Reproduction
drug DRUGBANK Phenylpropanolamine
drug DRUGBANK Diethylpropion
drug DRUGBANK Desmopressin
drug DRUGBANK Ibuprofen
disease IDO algorithm
drug DRUGBANK Sodium Tetradecyl Sulfate
drug DRUGBANK Indoleacetic acid
drug DRUGBANK Tacrine
drug DRUGBANK Adenosine 5′-phosphosulfate
drug DRUGBANK Acetylcholine
disease IDO process
drug DRUGBANK Phenindione
disease MESH uncertainty
drug DRUGBANK L-Phenylalanine
drug DRUGBANK Clotiazepam
drug DRUGBANK Diethylstilbestrol
disease MESH sti
drug DRUGBANK Esomeprazole
drug DRUGBANK Glycine
disease MESH emergency
drug DRUGBANK Ilex paraguariensis leaf
drug DRUGBANK Serine
disease MESH coronavirus infections
drug DRUGBANK Methionine
drug DRUGBANK Cefalotin
disease MESH causality
drug DRUGBANK Sulfasalazine
drug DRUGBANK Haloperidol
disease IDO symptom
drug DRUGBANK Cysteamine

Original Article

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