Publication date: Jul 30, 2025
We also monitor blood levels for rapamycin itself to ensure it doesnt hit an immunosuppressive dose, said Putrino. They laughed me out of the room, said Alex in an interview. So, last summer, he went to a telehealth provider called Healthspan that specializes in supplying rapamycin for longevity. The difference in her physical limitations was night and day, she said. Among 40 people with ME taking low-dose rapamycin over three months, 29 (72. 5%) showed improvements in fatigue, post-exertional malaise, and orthostatic intolerance. But he couldnt find a physician who would prescribe rapamycin, a drug that was emerging as a study target for the disease. The trial is expected to conclude in November 2026. At high doses, rapamycin suppresses the immune system. Continuous use of rapamycin can also block another vital protein complex called mTORC2, leading to diabetes-like symptoms.
| Concepts | Keywords |
|---|---|
| Basketball | Alex |
| Cancer | Clinical |
| June | Covid |
| Minimizing | Dose |
| Nashville | Drug |
| Long | |
| Low | |
| Months | |
| Prescribing | |
| Rapamycin | |
| Said | |
| Sick | |
| Trial | |
| Trials | |
| Year |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | orthostatic intolerance |
| pathway | REACTOME | Infectious disease |
| disease | MESH | infectious disease |
| disease | MESH | allergies |
| disease | MESH | T-cell exhaustion |
| pathway | REACTOME | Immune System |
| disease | IDO | quality |
| drug | DRUGBANK | Metformin |
| disease | IDO | blood |
| disease | MESH | viral infection |
| disease | IDO | protein |
| disease | IDO | process |
| disease | IDO | history |
| disease | IDO | bacteria |
| drug | DRUGBANK | Naltrexone |
| disease | MESH | infection |
| drug | DRUGBANK | Spinosad |
| pathway | REACTOME | Autophagy |
| disease | MESH | relapse |
| disease | MESH | Chronic Illness |
| disease | MESH | Long COVID |
| disease | MESH | myalgic encephalomyelitis |
| drug | DRUGBANK | Sirolimus |
| disease | MESH | cancer |