Publication date: Jul 29, 2025
System serology offers a comprehensive approach to evaluate the humoral immune response by evaluating multiple parameters. In the present study, based on four groups of individuals with a different history of SARS-CoV-2 immunization, we analyzed the serum of 180 individuals based on six serological methods to better decipher their immunity. Through our analysis, against different SARS-CoV-2 antigens or variants, we report the importance of system serology to better decipher population immunity. Fc-dependent parameters are key factors underlying the variability of humoral immune response triggered by different schemes of SARS-CoV-2 immunization. With an evolving exposure to new variants, the acquisition of robust cross-reactive Fc-dependent effector functions are likely to be key to control viral replication when neutralizing antibodies are poorly cross-reactive. As booster vaccination remains a useful tool in periodically bolstering humoral immunity, particularly in vulnerable populations, studies should continue to evaluate the humoral immune response using system serology approach.
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| Concepts | Keywords |
|---|---|
| Antibodies | Based |
| History | Cov |
| Humoral | Decipher |
| Vaccination | Evaluate |
| Viral | Fc |
| Humoral | |
| Immune | |
| Immunity | |
| Immunization | |
| Individuals | |
| Parameters | |
| Sars | |
| Serology | |
| System | |
| Variants |