Publication date: Jul 02, 2025
Background: Herpes zoster (HZ), resulting from the reactivation of latent varicella-zoster virus, has been increasingly observed in individuals following COVID-19. Given the shared immunological disturbances between the two conditions, this study aimed to investigate whether HZ following COVID-19 is associated with an elevated risk of renal, infectious, and autoimmune complications. Methods: This retrospective cohort study utilized data from the TriNetX global federated health network, encompassing over 9 million adults diagnosed with COVID-19 between January 2020 and January 2022. Patients who developed HZ within one year following COVID-19 diagnosis were compared to 1:1 propensity score-matched controls without HZ. Time-to-event analyses over a three-year follow-up period were conducted to estimate the risks of major adverse kidney events (MAKE; defined as acute kidney injury, dialysis dependence, or severely reduced kidney function with eGFR
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| Concepts | Keywords |
|---|---|
| Biomedicines | autoimmune disease |
| January | COVID-19 |
| Kidney | herpes zoster |
| Retrospective | kidney injury |
| Virus | rheumatoid arthritis |
| sepsis |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Herpes Zoster |
| disease | MESH | COVID-19 |
| disease | MESH | Complications |
| disease | MESH | acute kidney injury |
| drug | DRUGBANK | Coenzyme M |
| disease | MESH | autoimmune disease |
| disease | MESH | rheumatoid arthritis |
| pathway | KEGG | Rheumatoid arthritis |
| disease | MESH | sepsis |