Influencing factors of early neurological deterioration in COVID-19 -associated acute ischemic stroke.

Publication date: Jul 27, 2025

Coronavirus Disease-2019 (COVID-19) contributes to dysfunction and increased mortality in patients with acute ischemic stroke (AIS). However, whether COVID-19 causes early neurological deterioration (END) in patients with AIS and its underlying influencing factors are currently unclear. To ascertain the autonomous risk factors associated with END in stroke cases related to COVID-19. This is a retrospective observational study of data collected from November 2022 to February 2023 from patients with AIS complicated with COVID-19. The patients were divided into non-END and END groups, and their demographic characteristics, laboratory and imaging data were analyzed to investigate the risk factors for END in AIS patients complicated with COVID-19. A total of 83 patients were enrolled in this study, and divided in to END (n = 22) and non-END (n = 61) groups. We found that patients with high baseline the National Institutes of Health Stroke Scale (NIHSS) score (P = 0. 044), preexisting diabetes (P 

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Concepts Keywords
Coronavirus Acute ischemic stroke
Diabetes Aged
February Aged, 80 and over
Ischemic C-Reactive Protein
C-Reactive Protein
COVID-19
COVID-19
Early neurological deterioration
Female
fibrin fragment D
Humans
Ischemic Stroke
Male
Middle Aged
Retrospective Studies
Risk Factors
Risk factors
SARS-CoV-2

Semantics

Type Source Name
disease MESH COVID-19
disease MESH acute ischemic stroke
pathway KEGG Coronavirus disease
disease MESH causes
disease MESH stroke

Original Article

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