Publication date: Jul 30, 2025
Genes associated with neuronal metabolism and activity are deregulated in the brains of these animals, echoing similar processes observed in neurodegenerative diseases. Our study has enabled us to identify a list of genes that are deregulated in the long term by SARS-CoV-2 infection. It therefore appears that the virus is able to persist at low levels in the brainstem. The scientists subsequently investigated the impact of this viral RNA on brain metabolism. Further analysis revealed viral replication activity in tissues, suggesting that the virus can continue to infect new cells even though the viral load is low. An assessment of these symptoms moreover revealed that these behavioral symptoms differed according to the animals’ sex. “Our study is the first to reveal the long-term biological impact of SARS-CoV-2 infection in animal models. Symptoms can persist in some SARS-CoV-2 patients several months after infection.
| Concepts | Keywords |
|---|---|
| 2025anthony | Activity |
| Headaches | Brainstem |
| July | Cit |
| Lyssavirus | Cov |
| Scientists | Covid |
| Epidemiology | |
| Infection | |
| Institut | |
| Long | |
| Paris | |
| Pasteur | |
| Sars | |
| Symptoms | |
| Universit | |
| Virus |
Semantics
| Type | Source | Name |
|---|---|---|
| pathway | REACTOME | SARS-CoV-2 Infection |
| disease | MESH | shortness of breath |
| disease | MESH | tachycardia |
| disease | MESH | brain fog |
| disease | MESH | complications |
| disease | MESH | syndrome |
| disease | MESH | COVID-19 pandemic |
| pathway | REACTOME | Neurodegenerative Diseases |
| disease | MESH | neurodegenerative diseases |
| pathway | REACTOME | Metabolism |
| disease | MESH | anxiety |
| disease | MESH | depression |
| disease | IDO | acute infection |
| disease | MESH | infection |
| disease | MESH | Long COVID |
| disease | IDO | facility |
| drug | DRUGBANK | Huperzine B |
| disease | MESH | Infectious Diseases |
| drug | DRUGBANK | L-Citrulline |
| drug | DRUGBANK | Dopamine |
| disease | IDO | production |
| pathway | KEGG | Viral replication |
| disease | MESH | viral load |