Publication date: Jun 30, 2025

Delirium is a common and underrecognized complication among critically ill patients, associated with prolonged ICU stays, cognitive dysfunction, and increased mortality. Its multifactorial causes and fluctuating course hinder early prediction, limiting timely management. Predictive models based on data available at ICU admission may help to identify high-risk patients and guide early interventions. This study evaluated machine learning models used to predict delirium in critically ill patients with SARS-CoV-2 infections using a prospective cohort of 426 patients. The dataset included demographic characteristics, clinical data (e. g., comorbidities, medication, reason for ICU admission, interventions), and routine lab test results. Five models-Logistic Regression, Support Vector Machine, Decision Tree, Random Forest, and NacEFve Bayes-were developed using 112 features. Feature selection relied on Information Gain, and model performance was assessed via 10-fold cross-validation. The NacEFve Bayes model showed moderate predictive performance and high interpretability, achieving an AUC of 0. 717, accuracy of 65. 3%, sensitivity of 62. 4%, specificity of 68. 1%, and precision of 66. 2%. Key predictors included invasive mechanical ventilation, deep sedation with benzodiazepines, SARS-CoV-2 as the reason for ICU admission, ECMO use, constipation, and male sex. These findings support the use of interpretable models for early delirium risk stratification using routinely available ICU data.

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