Research and Clinical Progress of Therapeutic Tumor Vaccines.

ingentiumby ingentium

In Vaccines Literature.

Publication date: Jun 23, 2025

Therapeutic cancer vaccines are a new growth point of biomedicine with broad industrial prospects in the post-COVID-19 era. Many large international pharmaceutical companies and emerging biotechnology companies are deploying different tumor therapeutic cancer vaccine projects, focusing on promoting their clinical transformation, and the vaccine industry has strong momentum for development. Such vaccines are also the core engine and pilot site for the development of new vaccine targets, new vectors, new adjuvants, and new technologies, which play a key role in promoting the innovation and development of vaccines. Various therapeutic cancer vaccines, such as viral vector vaccines, bacterial vector vaccines, cell vector vaccines, peptide vaccines, and nucleic acid vaccines, have all been applied in clinical research. With the continuous development of technology, therapeutic cancer vaccines are evolving towards the trends of precise antigens, efficient carriers, diversified adjuvants, and combined applications. For instance, the rapidly advancing mRNA-4157 vaccine is a typical representative that combines personalized antigens with efficient delivery vectors (lipid nanoparticles, LNPs), and it also shows synergistic advantages in melanoma patients treated in combination with immune checkpoint inhibitors. In this article, we will systematically discuss the current research and development status and clinical research progress of various therapeutic cancer vaccines.

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Concepts Keywords
Biotechnology clinical progress
Efficient therapeutic tumor vaccines
Melanoma
Viral

Semantics

Type Source Name
disease MESH COVID-19
disease MESH tumor
disease IDO site
disease IDO role
disease IDO cell
disease MESH melanoma
pathway KEGG Melanoma
drug DRUGBANK Coenzyme M
pathway REACTOME Immune System
drug DRUGBANK BCG vaccine
disease MESH prostate cancer
pathway KEGG Prostate cancer
disease MESH renal carcinoma
disease IDO nucleic acid
disease IDO blood
disease IDO bacteria
pathway REACTOME Apoptosis
disease MESH lung cancer
disease MESH glioblastoma
disease MESH breast cancer
pathway KEGG Breast cancer
disease MESH liver cancer
disease MESH infection
disease MESH squamous carcinoma
disease MESH glioma
pathway KEGG Glioma
disease IDO immune response
disease MESH ovarian cancer
disease MESH papilloma
disease MESH airway obstruction
disease MESH cholangiocarcinoma
disease MESH varicella
drug DRUGBANK Sorafenib
disease MESH hepatocellular carcinoma
pathway KEGG Hepatocellular carcinoma
disease MESH cervical intraepithelial neoplasia
disease MESH brain tumors
drug DRUGBANK Trestolone
disease IDO immunosuppression
drug DRUGBANK Veledimex
disease MESH Neuroendocrine tumors
drug DRUGBANK Galiximab
disease MESH Sarcoma
disease MESH mesothelioma
drug DRUGBANK Celecoxib
drug DRUGBANK Gemcitabine
drug DRUGBANK Chlorotrianisene
drug DRUGBANK Lenvatinib
drug DRUGBANK Regorafenib
disease MESH Retinoblastoma
drug DRUGBANK Cyclophosphamide
drug DRUGBANK Paclitaxel
disease MESH carcinoma
drug DRUGBANK G207
disease MESH metastases
drug DRUGBANK Cisplatin
disease MESH Multiple myeloma
disease IDO protein
disease MESH kidney cancer
drug DRUGBANK Temozolomide
disease MESH lymphoma
disease MESH shock
drug DRUGBANK Cycloserine
disease MESH Plasmacytoma
disease MESH Medulloblastoma
disease MESH acute lymphoblastic leukemia
drug DRUGBANK Carboplatin
drug DRUGBANK Cabozantinib
disease MESH Acute myeloid leukemia
pathway KEGG Acute myeloid leukemia
drug DRUGBANK Nivolumab
drug DRUGBANK Ipilimumab
disease MESH neuroblastoma
drug DRUGBANK Pembrolizumab
disease IDO production
disease MESH leukemia
disease MESH Myelodysplastic syndrome Acute myeloid leukemia
disease MESH Myeloid leukemia
drug DRUGBANK Lenalidomide
disease MESH noma
drug DRUGBANK Imiquimod
disease IDO pathogen
drug DRUGBANK Vitespen
drug DRUGBANK Racotumomab
disease MESH cervical cancer
disease MESH small cell lung cancer
pathway KEGG Small cell lung cancer
disease MESH defects
disease MESH recurrence
drug DRUGBANK Nelipepimut-S
disease MESH ductal carcinoma
disease MESH DCIS
drug DRUGBANK Guanosine
disease MESH adenocarcinoma
drug DRUGBANK Esomeprazole
disease MESH Smoldering multiple myeloma
drug DRUGBANK Cefadroxil
disease IDO host
disease MESH immune tolerance
disease MESH skin cancers
disease MESH Chordoma
drug DRUGBANK Protamine
drug DRUGBANK Omega-3 fatty acids
drug DRUGBANK Cholesterol
pathway REACTOME Translation
disease MESH Digestive system neoplasms
disease IDO process
pathway REACTOME Release
disease IDO quality
disease MESH hematological malignancies
disease MESH Vesicular Stomatitis
disease IDO replication
disease MESH Recurrent Respiratory Papillomatosis
disease MESH vaccinia
disease MESH Oropharyngeal Cancer
drug DRUGBANK L-Aspartic Acid
drug DRUGBANK Acetylsalicylic acid
disease MESH Death
drug DRUGBANK Avelumab
disease MESH Colorectal Cancer
pathway KEGG Colorectal cancer
disease MESH Pancreatic Cancer
pathway KEGG Pancreatic cancer
disease MESH Suicide
disease MESH Astrocytoma
disease MESH Malignant Pleural Mesothelioma
disease MESH Malignant Pleural Effusions
disease MESH Alveolar Soft Part Sarcoma
disease MESH Neck Cancer
disease MESH Thrombosis
disease MESH Gastric Cancer
pathway KEGG Gastric cancer
disease MESH Triple negative Breast Cancer
drug DRUGBANK 2′-Deoxycytidine
drug DRUGBANK Dasatinib
disease MESH Lynch Syndrome
drug DRUGBANK Carboxyamidotriazole
drug DRUGBANK Trastuzumab
drug DRUGBANK Atezolizumab
drug DRUGBANK Bevacizumab
pathway REACTOME Mismatch Repair
drug DRUGBANK Pertuzumab
disease MESH Endometrial Cancer
pathway KEGG Endometrial cancer
drug DRUGBANK Tricyclazole
disease MESH Hepatitis
disease MESH Esophagus Cancer
drug DRUGBANK Natural alpha interferon
drug DRUGBANK (S)-Des-Me-Ampa
drug DRUGBANK Guanine
drug DRUGBANK Mannose
disease MESH Bladder Cancer
pathway KEGG Bladder cancer
drug DRUGBANK Azacitidine
disease MESH Fibrolamellar Hepatocellular Carcinoma
drug DRUGBANK Inosine
disease MESH HPV Infection
drug DRUGBANK Durvalumab
drug DRUGBANK Troleandomycin
drug DRUGBANK Gold
drug DRUGBANK Cemiplimab
disease IDO ribonucleic acid
drug DRUGBANK Methionine

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