Publication date: Sep 01, 2025
Diabetes mellitus (DM) increases susceptibility to infection and worsens outcomes in sepsis, a leading cause of preventable death. However, population-level trends in sepsis-related mortality among diabetic individuals in the United States (US) remain poorly characterised, especially in the context of the COVID-19 pandemic. This study evaluates national patterns, temporal shifts, and demographic disparities in sepsis-related mortality in diabetic patients from 1999 to 2023. We conducted a retrospective analysis using the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) Multiple Cause of Death database. Sepsis-related deaths with co-listed DM were extracted for US adults between 1999 and 2023. Age-adjusted mortality rates (AAMRs) were calculated and Joinpoint regression was used to estimate annual percentage changes (APCs) and identify significant trends. A total of 483,207 sepsis-related deaths occurred in individuals with DM during the study period. AAMRs declined significantly from 1999 to 2018 (APC: -1. 22; p
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Diabetes Mellitus |
| disease | MESH | Sepsis |
| disease | IDO | susceptibility |
| disease | MESH | infection |
| disease | MESH | death |
| disease | MESH | COVID-19 pandemic |
| disease | MESH | Cause of Death |
| disease | MESH | Health Status |
| disease | MESH | septic shock |