Publication date: Jul 30, 2025
COVID-19-associated pulmonary aspergillosis (CAPA) significantly exacerbates the clinical outcomes of COVID-19 patients, contributing to heightened mortality. Aspergillus tracheobronchitis, a manifestation of invasive pulmonary aspergillosis, specifically involves the tracheobronchial tree. According to the 2020 European Confederation of Medical Mycology/International Society for Human and Animal Mycology (ECMM/ISHAM) consensus criteria, airway biopsy via bronchoscopy is the definitive method for CAPA diagnosis, underscoring its critical role in the management of COVID-19 patients. This case report describes an elderly male patient with COVID-19 who presented with extensive pseudomembranous involvement of the tracheobronchial tree, identified through bronchoscopy. The pseudomembrane, spanning from the glottis to the bronchi and characterized by its yellow-white translucency, was removed. Subsequent pathological examination and next-generation sequencing confirmed an Aspergillus infection. Despite the initiation of antifungal therapy, the patient’s condition deteriorated, leading to his death.
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Acute Respiratory Distress Syndrome |
| disease | MESH | COVID-19 |
| disease | MESH | Pulmonary Aspergillosis |
| disease | MESH | invasive pulmonary aspergillosis |
| disease | IDO | role |
| disease | MESH | Aspergillus infection |
| disease | MESH | death |
| disease | MESH | Fatal Outcome |
| disease | MESH | Fungal infection |