Publication date: Sep 01, 2025
The X-linked TLR7 rs179008 T allele has been associated with altered antiviral immunity. Given their shared inflammatory pathways and higher pediatric mortality rates in Brazil during the pandemic, we investigated their association with multisystem inflammatory syndrome in children (MIS-C) together with Kawasaki disease (KS) following SARS-CoV-2 infection. A cross-sectional study (2021-2022) analyzed 73 hospitalized children (
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| Concepts | Keywords |
|---|---|
| Allele | Kawasaki-like syndrome |
| Kawasaki | rs179008 T |
| Pandemic | SARS-CoV-2 |
| Pediatric | TLR7 |
| toll like receptor |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Multisystem Inflammatory Syndrome in Children |
| disease | MESH | Syndrome |
| disease | MESH | Kawasaki disease |
| disease | MESH | SARS-CoV-2 infection |
| pathway | REACTOME | SARS-CoV-2 Infection |
| drug | DRUGBANK | Coenzyme M |
Original Article
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