A post-COVID-19 upsurge in Group A Streptococcus in the Czech Republic was driven by emm1 and emm12 with shared virulence factors.

A post-COVID-19 upsurge in Group A Streptococcus in the Czech Republic was driven by emm1 and emm12 with shared virulence factors.

Publication date: Oct 01, 2025

In 2023, a significant increase in Streptococcus pyogenes, Group A Streptococcus (GAS) culture positivity was observed in Czech microbiological laboratories. We conducted a multicentre study to obtain epidemiological data and characterise circulating strains. Eleven microbiology departments provided data on single-patient GAS-positive cultures from 2017 to 2023. Additionally, 10 consecutive, single-patient GAS isolates from 12 hospitals were submitted in May 2023 for whole-genome sequencing and antimicrobial susceptibility testing. In 2023, there was a significant increase in GAS-positive cultures compared to the periods of 2017-2019 (p = 0. 002), 2020-2021 (p 

Concepts Keywords
Czech Adolescent
Hospitals Adult
Microbiology Anti-Bacterial Agents
Upsurge Anti-Bacterial Agents
Antigens, Bacterial
Antigens, Bacterial
Carrier Proteins
Carrier Proteins
Child
Child, Preschool
COVID-19
Czech Republic
drs12.02 gene
Female
Humans
Infant
Male
Middle Aged
Multilocus Sequence Typing
SARS-CoV-2
sic gene
Streptococcal Infections
streptococcal M protein
Streptococcus pyogenes
Streptodornase
Surveillance
Virulence Factors
Virulence Factors
Whole Genome Sequencing

Semantics

Type Source Name
disease MESH COVID-19
disease IDO susceptibility
disease MESH Streptococcal Infections

Original Article

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