Publication date: Sep 08, 2025
Erythrodontium julaceum, Marchantia polymorpha, and Plagiochila bantamensis are widely distributed bryophytes in Vietnam. However, comprehensive chemical and biological data on their composition remain limited. Bio-guided isolation based on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) M inhibition was applied to these species, resulting in the identification of 23 metabolites. Compound P8 is a new natural compound. Subsequently, the SARS-CoV-2 M inhibition of the isolated compounds revealed that bisbibenzyl- and 3-benzylphthalide-type compounds exhibit bioactivity. Among the tested compounds, isoriccardin C (M2) and julacelide (E1) exhibited significant activity, with IC values of 15. 7 and 2. 84 ug/mL, respectively. Molecular docking results further supported their strong activity.
| Concepts | Keywords |
|---|---|
| Benzylphthalide | 3‐benzylphthalide |
| Bioactivity | bisbibenzyl |
| Coronavirus | Erythrodontium julaceum |
| Severe | Marchantia polymorpha |
| Vietnamese | Plagiochila bantamensis |