Publication date: Sep 05, 2025
Negative respiratory outcomes have been reported in people diagnosed with COVID-19. Breast cancer, the most common cancer diagnosed in women globally, is an important cancer to investigate regarding COVID-19 outcomes. We hypothesized that women with breast cancer and infected with COVID-19 would demonstrate a greater risk for negative respiratory outcomes than people without breast cancer. We sought to examine associations between breast cancer diagnosis, COVID-19 infection, and negative respiratory outcomes using an Oracle Real World dataset. Horn and Gassaway’s Practice-Based Evidence Framework structured this retrospective cohort study. Regression analysis identified associations among negative respiratory outcomes and breast cancer and COVID-19 diagnosis. Associations between preexisting comorbidities and COVID-19 infection complications in the dataset were also examined. Breast cancer and COVID-19 diagnoses significantly predict increased odds of developing a negative respiratory outcome (OR = 1. 11, CI 1. 01-1. 23, P = . 03). Additional predictors of negative respiratory outcomes include advanced age (OR = 4. 88, CI 4. 21-5. 65, P
| Concepts | Keywords |
|---|---|
| Black | breast cancer |
| Cancer | COVID-19 |
| Oracle | Oracle Real-World data |
| Preexisting | respiratory disease |
| Women |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Breast Cancer |
| pathway | KEGG | Breast cancer |
| disease | MESH | COVID-19 |
| disease | MESH | Infection |
| disease | MESH | cancer |
| disease | MESH | complications |
| disease | MESH | Long Covid |