Publication date: Sep 10, 2025
Glycoprotein VI (GPVI), a key platelet receptor, mediates collagen-induced platelet activation and interacts with fibrin to promote thrombus growth. Studies demonstrate the mechanisms of GPVI in thrombosis, showing its inhibition reduces thrombosis without impairing hemostasis, consistent with the mild bleeding phenotype in GPVI-deficient individuals. GPVI is also implicated in inflammation and cancer. This review introduces the mechanism of GPVI in thrombosis and highlights two investigational GPVI-targeting drugs (glenzocimab and Revacept), summarizing current evidence and future directions for this novel anti-thrombotic approach. Therapeutic targeting of glycoprotein VI (GPVI) with inhibitors such as glenzocimab and Revacept. This graphic summarizes the transition from preclinical evidence, which established antithrombotic efficacy without increasing bleeding risk, to ongoing clinical evaluation across several conditions including acute ischemic stroke, myocardial infarction, COVID-19, and symptomatic carotid stenosis. The figure is created with BioRender. Teaser: This review highlights the multifaceted roles of GPVI in thrombosis, inflammation, and cancer, while summarizing the latest advances in GPVI-targeted drug development, offering new insights for therapeutic intervention in related diseases.
| Concepts | Keywords |
|---|---|
| Antithrombotic | cardiovascular |
| Biorender | GPVI |
| Cancer | hemostasis |
| Discov | platelet |
| Today | thrombosis |
Semantics
| Type | Source | Name |
|---|---|---|
| pathway | KEGG | Platelet activation |
| disease | MESH | thrombus |
| pathway | REACTOME | Hemostasis |
| disease | MESH | bleeding |
| disease | MESH | inflammation |
| disease | MESH | cancer |
| disease | MESH | acute ischemic stroke |
| disease | MESH | myocardial infarction |
| disease | MESH | COVID-19 |
| disease | MESH | carotid stenosis |
| disease | IDO | intervention |