CLAE: A High-Fidelity Nanopore Sequencing Strategy for Read-Level Viral Variant Detection and Environmental RNA Virus Discovery.

Publication date: Sep 11, 2025

High-fidelity (HF) long-read sequencing enables accurate profiling of microorganisms and pathogens at single-molecule resolution. However, current Oxford Nanopore Technologies (ONT)-a revolutionary platform offering real-time, portable sequencing at relatively low instrumental cost-suffer from severe read-length bias, limited accuracy (often

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