Effectiveness of 2024/25 KP.2 vaccine against outpatient COVID-19 in Canada

Publication date: Sep 10, 2025

Between November 2024 and April 2025, the Canadian Sentinel Practitioner Surveillance Network assessed KP.2 vaccine effectiveness against outpatient COVID-19 by test-negative design. Vaccination protected best during the first two months, reducing risk by two-thirds among vaccinated versus unvaccinated individuals, declining by 3-4 months, and reducing the risk overall by half.

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Concepts Keywords
Canadian Canada
Influenza Covid
Microbiology Effectiveness
S1473309925003809 Estimates
Https
Kp
Medrxiv
Preprint
Sars
Season
September
Vaccination
Vaccine
Vaccines
Weeks

Semantics

Type Source Name
disease MESH COVID-19
disease MESH infection
pathway KEGG Coronavirus disease
disease MESH emergency
disease MESH influenza
disease MESH Infectious Diseases
drug DRUGBANK Fosfomycin
disease MESH death

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