Publication date: Sep 12, 2025
Persistent olfactory dysfunction (OD) and cognitive impairment are among the most frequently reported sequelae of long term infection with SARS-CoV-2 (long COVID-19). However, the association between these conditions remains unclear. This study investigated the correlation between OD and cognitive impairment in patients recovering from COVID-19 to identify the implications for therapeutic and rehabilitation strategies. A cross-sectional study of adult patients diagnosed with long COVID was conducted at a healthcare centre in Brazil. Olfactory function was assessed using the Connecticut Chemosensory Clinical Research Centre (CCCRC) test, and cognitive performance was evaluated using the Montreal Cognitive Assessment (MoCA). Statistical analyses included odds ratios (OR) and linear regression to explore the association between OD severity and cognitive scores, adjusting for potential confounders such as age, sex, and comorbidities. A total of 241 patients (age: 48. 60 +/- 12. 68 years; 73% female) were included. Cognitive impairment (MoCA
| Concepts | Keywords |
|---|---|
| Brazil | Cognitive impairment |
| Connecticut | COVID-19 |
| Covid | Long COVID |
| Female | Olfactory dysfunction |
| Psychiatry |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | cognitive impairment |
| disease | MESH | long COVID |
| disease | MESH | syndrome |
| disease | MESH | sequelae |
| disease | MESH | long term infection |
| disease | MESH | COVID-19 |