Anti-Inflammatory and Antioxidant Effects of HIIT in Individuals with Long COVID: Insights into the Potential Role of Triphala.

ingentiumby ingentium

In Long Covid Literature.

Anti-Inflammatory and Antioxidant Effects of HIIT in Individuals with Long COVID: Insights into the Potential Role of Triphala.

Publication date: Sep 04, 2025

Long COVID is characterized by persistent symptoms associated with chronic inflammation and oxidative stress. While high-intensity interval training (HIIT) and supplementation with antioxidants such as Triphala have demonstrated individual therapeutic benefits, their combined effects remain unclear. This study aimed primarily to evaluate the effects of an 8-week HIIT program on markers of inflammation, oxidative stress, and exercise-related symptoms in individuals with long COVID, and secondarily to explore whether Triphala supplementation provided additional benefits. A total of 104 participants (aged 18-59 years) were randomized into three groups-control (placebo), HIIT (cycling for 28 min/day, 3 days/week), and combined (HIIT + Triphala, 1000 mg/day)-for 8 weeks. The biomarkers assessed included interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), protein carbonyls, and superoxide dismutase (SOD) activity. Following the intervention, significant reductions in IFN-γ, TNF-α, MDA, protein carbonyls, and rating of perceived exertion were observed in both the HIIT and combined groups (p

Open Access PDF

Concepts Keywords
Biomarkers exercise therapy
Malondialdehyde inflammation
Training long COVID
Tumor oxidative stress
Week phytotherapy

Semantics

Type Source Name
disease MESH Long COVID
disease IDO role
disease MESH inflammation
disease MESH oxidative stress
disease IDO protein
disease IDO intervention
disease MESH dyspnea
disease MESH COVID 19
disease IDO acute infection
disease MESH chronic infection
disease MESH thrombosis
disease MESH syndrome
disease MESH morbidity
disease MESH complications
drug DRUGBANK Coenzyme M
disease MESH chronic fatigue syndrome
disease MESH infection
disease MESH hypotension
disease IDO blood
drug DRUGBANK Creatinine
pathway REACTOME Mitochondrial biogenesis
disease MESH metabolic syndrome
drug DRUGBANK Fibrinogen Human
drug DRUGBANK Isoxaflutole
disease IDO production
drug DRUGBANK Oxygen
pathway KEGG Oxidative phosphorylation
drug DRUGBANK Nitric Oxide
disease MESH lifestyle factors
drug DRUGBANK Ethanol
drug DRUGBANK Tannic acid
drug DRUGBANK Epicatechin
drug DRUGBANK Ascorbic acid
disease MESH symptom exacerbation
disease MESH hair loss
disease MESH food allergies
disease MESH hypertension
disease MESH cardiovascular disease
disease MESH cerebrovascular disease
disease MESH cancer
disease MESH kidney disease
disease MESH infectious diseases
disease IDO facility
disease IDO process
drug DRUGBANK Medical air
drug DRUGBANK Helium
drug DRUGBANK Methyl salicylate
drug DRUGBANK Butorphanol
drug DRUGBANK Tocopherol
drug DRUGBANK beta-Sitosterol
drug DRUGBANK Lupeol
drug DRUGBANK Oleic Acid
drug DRUGBANK Linoleic acid
drug DRUGBANK Squalene
drug DRUGBANK Trestolone
disease IDO assay
drug DRUGBANK Edetic Acid
drug DRUGBANK Sodium lauryl sulfate
drug DRUGBANK Water

Original Article

(Visited 7 times, 1 visits today)

Leave a Comment

Your email address will not be published. Required fields are marked *