Publication date: Sep 04, 2025
Background/Objectives: Vitamin D is involved in immune regulation, and deficiency may increase susceptibility to SARS-CoV-2 infection. This study assessed vitamin D status and examined associations between serum 25-hydroxyvitamin D (25(OH)D) concentrations and demographic, anthropometric, and clinical factors, including SARS-CoV-2 infection, in a diverse urban UK patient population. Methods: We analysed 25(OH)D concentrations in 17,619 pre-COVID-19 vaccine patients (62% female) whose samples were routinely processed between January and June 2020 at St Thomas’ Hospital, London, UK. SARS-CoV-2 RNA/IgG test results (March 2020-January 2021) were linked to these records. Associations were examined with age, BMI, sex, ethnicity, and laboratory data. Vitamin D deficiency was defined as 25(OH)D
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| Concepts | Keywords |
|---|---|
| Female | age |
| Hydroxyvitamin | COVID-19 |
| London | ethnicity |
| Pandemic | infection |
| inflammation | |
| SARS-CoV-2 | |
| vitamin D |
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Vitamin D |
| disease | MESH | COVID-19 Pandemic |
| disease | IDO | susceptibility |
| pathway | REACTOME | SARS-CoV-2 Infection |
| disease | MESH | Vitamin D deficiency |
| drug | DRUGBANK | Potassium Chloride |
| disease | MESH | Vitamin deficiency |
| drug | DRUGBANK | Calcium |
| drug | DRUGBANK | Phosphate ion |
| drug | DRUGBANK | Magnesium |
| drug | DRUGBANK | Folic Acid |
| drug | DRUGBANK | Methacholine |
| drug | DRUGBANK | Parathyroid hormone |
| disease | MESH | underweight |
| disease | MESH | overweight |
| disease | MESH | infection |
| disease | MESH | inflammation |