Publication date: Sep 18, 2025
Importantly, the researchers found a strong correlation between blood IgA(S) levels and nasal IgA(S) levels, suggesting that blood tests can reliably indicate the strength of immune protection in airways. As a result, measuring blood IgA(S) levels after vaccination may help identify individuals at higher risk for breakthrough infection, especially among vulnerable groups. Researchers tracked individuals’ antibody levels after vaccinations and identified four distinct patterns of immune response after the first booster vaccination. The findings suggest that monitoring how antibody levels change over time could assist in identifying individuals at greater risk of infection. People with lower blood levels of IgA(S) antibodies, which protect the nose and throat, were also at higher risk. Notably, the group that started with the highest antibody levels but experienced a faster decline were infected earlier. A breakthrough or subsequent infection refers to infections that occur after vaccination because the virus overcomes the immune protection that vaccines provide.
| Concepts | Keywords |
|---|---|
| Fast | Antibodies |
| Genetic | Antibody |
| Japan | Blood |
| Months | Breakthrough |
| Vaccinations | Covid |
| Group | |
| Igas | |
| Immune | |
| Infection | |
| Protection | |
| Rapid | |
| Responders | |
| Risk | |
| Vaccination | |
| Vulnerable |