Three-layered semantic framework for public health intelligence.

Three-layered semantic framework for public health intelligence.

Publication date: Sep 15, 2025

Disease surveillance systems play a crucial role in monitoring and preventing infectious diseases. However, the current landscape, primarily focused on fragmented health data, poses challenges to contextual understanding and decision-making. This paper addresses this issue by proposing a semantic framework using ontologies to provide a unified data representation for seamless integration. The paper demonstrates the effectiveness of this approach using a case study of a COVID-19 incident at a football game in Italy. In this study, we undertook a comprehensive approach to gather and analyze data for the development of ontologies within the realm of pandemic intelligence. Multiple ontologies were meticulously crafted to cater to different domains related to pandemic intelligence, such as healthcare systems, mass gatherings, travel, and diseases. The ontologies were classified into top-level, domain, and application layers. This classification facilitated the development of a three-layered architecture, promoting reusability, and consistency in knowledge representation, and serving as the backbone of our semantic framework. Through the utilization of our semantic framework, we accomplished semantic enrichment of both structured and unstructured data. The integration of data from diverse sources involved mapping to ontology concepts, leading to the creation and storage of RDF triples in the triple store. This process resulted in the construction of linked data, ultimately enhancing the discoverability and accessibility of valuable insights. Furthermore, our anomaly detection algorithm effectively leveraged knowledge graphs extracted from the triple store, employing semantic relationships to discern patterns and anomalies within the data. Notably, this capability was exemplified by the identification of correlations between a football game and a COVID-19 event occurring at the same location and time. The framework showcased its capability to address intricate, multi-domain queries and support diverse levels of detail. Additionally, it demonstrated proficiency in data analysis and visualization, generating graphs that depict patterns and trends; however, challenges related to ontology maintenance, alignment, and mapping must be addressed for the approach’s optimal utilization.

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Concepts Keywords
Biomed Data integration
Football Data interoperability
Italy Ontology
Pandemic Public health intelligence
Valuable Semantic framework
Semantic web
Web of data

Semantics

Type Source Name
disease IDO role
disease MESH infectious diseases
disease MESH COVID-19
disease IDO process
disease IDO algorithm
disease MESH anomalies
pathway REACTOME Reproduction
drug DRUGBANK Trestolone
disease MESH emergency
disease IDO intervention
disease MESH malaria
pathway KEGG Malaria
disease MESH Brucellosis
disease MESH Dengue fever
disease MESH Meningitis
disease IDO contact tracing
disease MESH Infections
drug DRUGBANK Tropicamide
drug DRUGBANK Dexketoprofen
drug DRUGBANK Coenzyme M
disease IDO quality
disease MESH causes
disease IDO pathogen
disease IDO symptom
disease IDO object
disease IDO zoonosis
disease IDO infection
disease IDO history
disease IDO entity
drug DRUGBANK Tretamine
disease MESH tics
drug DRUGBANK Huperzine B
drug DRUGBANK Medical air
disease MESH Influenza
drug DRUGBANK Methionine
pathway REACTOME Translation
drug DRUGBANK Isosorbide Mononitrate
drug DRUGBANK Gold
disease MESH Healthcare Associated Infections
drug DRUGBANK Alpha-1-proteinase inhibitor

Original Article

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