Risk of perioperative mortality and venous thromboembolism after total hip or knee arthroplasty with recent COVID-19 infection: an observational study from the Kaiser Permanente Northern California Database.

Publication date: Sep 17, 2025

Limited data exist on venous thromboembolism (VTE) and mortality risk in patients undergoing primary total hip (THA) or knee arthroplasty (TKA) following recent COVID-19 infection. We aimed to evaluate whether the timing of COVID-19 infection affects postoperative VTE and mortality risk after THA or TKA. Adult Kaiser Permanente Northern California members undergoing elective THA or TKA from 2020-2022 were identified using internal procedure codes. 33,520 patients with or without SARS-CoV-2 within 6 months preoperatively were compared. Multivariate Poisson regression was used to calculate incidence rate ratios (RRs) adjusted for demographics, comorbidities, and Covid vaccination status. The primary outcome was 90-day VTE (deep venous thrombosis or pulmonary embolism). The secondary outcome was 90-day mortality. Among patients with recent COVID-19, the 90-day VTE rate was 0. 3%, and the mortality rate was 2. 5%. Recent COVID-19 within 6 to 12 weeks preoperatively did not significantly increase 90-day VTE risk (RR 1. 0, 95% confidence interval [CI] 0. 38-2. 8) but was associated with increased 90-day mortality risk (RR 3. 1, CI 1. 7-5. 4). Recent COVID-19 infection did not significantly impact VTE risk after THA or TKA. However, infection within 6 to 12 weeks preoperatively was associated with increased 90-day mortality.

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