Publication date: Sep 16, 2025
Human Leukocyte Antigen (HLA) genes play a crucial role in immune response against infectious disease. In this study, we aimed to investigate the frequency of HLA alleles in kidney transplant patients diagnosed with COVID-19 and explore potential associations with disease severity. Kidney transplant patients who were diagnosed with COVID-19 and followed up at the Istanbul Medical Faculty Hospital kidney transplant clinic between March 2020 and January 2023 were included in this study. All patients were genotyped for HLA loci (HLA-A,-B,-DRB1) at low resolution using the Luminex method. Patients were classified as mild, moderate, and severe according to COVID-19 severity. In a study of 332 kidney transplant patients, 52 developed severe COVID-19, with 24 deaths. Severe cases were older and had higher rates of hospitalization, Intensive Care Unit (ICU) admissions, acute kidney injury, and mortality (all P
| Concepts | Keywords |
|---|---|
| Allele | Admissions |
| Hospitalization | Alleles |
| Istanbul | Covid |
| January | Diagnosed |
| Kidney | Disease |
| Drb1 | |
| Higher | |
| Hla | |
| Hospital | |
| Icu | |
| Kidney | |
| Severe | |
| Severity | |
| Study | |
| Transplant |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| disease | IDO | role |
| disease | IDO | immune response |
| disease | MESH | infectious disease |
| pathway | REACTOME | Infectious disease |
| disease | MESH | acute kidney injury |
| disease | MESH | cardiovascular disease |
| disease | IDO | susceptibility |
| disease | MESH | infection |
| disease | MESH | Long Covid |