Comparison of neonatal outcomes from mothers with and without COVID-19 in a tertiary referral hospital in Jakarta, Indonesia, neonatal COVID-19 in Indonesia.

Publication date: Sep 18, 2025

BackgroundCoronavirus disease 2019 (COVID-19) in pregnant women and neonates may adversely affect neonatal outcome, but literature remains limited. MethodsThis is a retrospective analysis of all infants born to mothers with and without COVID-19 at an Indonesian national referral hospital between March and September 2020. ResultsA total of 393 neonates were delivered by 389 mothers, of whom 204 (52. 4%) had COVID-19. Symptomatic and asymptomatic mothers with COVID-19 had similar seropositivity rates (53. 6% vs 69. 8%, p = 0. 090). Neonates born to noninfected mothers were more likely to experience asphyxia at minute 1 of life (p = 0. 005), to be diagnosed with TTN (p = 0. 048) and sepsis (p = 0. 022) and to require resuscitation (p = 0. 008) than those born to infected mothers. Nine (2. 4%) out of 377 tested infants were positive for SARS-CoV-2, of whom 4 had noninfected mothers. Neonates of mothers with symptomatic COVID-19 were less likely to be seropositive (30. 0% vs 52. 4%, p = 0. 024) and more likely to acquire COVID-19 (p = 0. 026) than those born to asymptomatically infected mothers. ConclusionThis study suggests that maternal COVID-19, particularly when occurring in late pregnancy, was not associated with an increase in acute neonatal complications.

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