Publication date: Sep 21, 2025
Clinical studies on COVID-19 patients revealed among multiple symptoms, uncontrolled production of inflammatory mediators. The current study presents the inhibitory effects of eleven terpenoid derivatives (1-11) and two naphthoquinones (12 and 13) on the main protease (Mpro) of SARS-CoV-2. All the terpenoids and compound 13 displayed weak inhibitory effects while compound 12 showed moderate inhibitory effects of M with IC of 50. 2 uM. Anti-inflammatory effects against pro-inflammatory mediators produced in LPS-induced lung injury and the cytotoxicity against Vero and THP-1 cell lines of molecules 12 and 13 were also evaluated. Molecules 12 and 13 presented promising anti-inflammatory activity by attenuating the exudation and neutrophil and leukocyte migration.
| Concepts | Keywords |
|---|---|
| Clinical | naphtoquinones |
| Covid | protease |
| Inflammatory | SARS-CoV-2 |
| Lps | selenium |
| Naphthoquinones | terpenic coumponds |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| disease | IDO | production |
| disease | MESH | lung injury |
| disease | IDO | cell |
| drug | DRUGBANK | Selenium |